Dr. Stephen Kibet Moindi Publications 
1  9999  Stephen Moindi Kibet, G.P. Pokhariyal And B.M. Nzimbi, W_2Recurrent LPSasakian Manifold, Universal Journal Of Mathematics And Mathematical Sciences(UMMS) Accepted In May 2012. Paper Under Review. Click to View Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG halflife was 19.5 +/ 7.7 h in seven fast acetylators of DDS and 12.6 +/ 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/ 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/ 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/ 1.5% by fast and 1.9 +/ 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the halflives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to autoinduction of oxidative enzymes involved in AG metabolism. 
2  9999  Moindi, S.K., Pokhariyal, G.P. And Nzimbi, B.M., W_4Curvature Tensor On A AEinstein Sasakian Manifold, Global Journal Of Theoretical And Applied Mathematical Sciences(GJTAMS), Accepted Feb 2012, To Appear. Click to View Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG halflife was 19.5 +/ 7.7 h in seven fast acetylators of DDS and 12.6 +/ 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/ 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/ 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/ 1.5% by fast and 1.9 +/ 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the halflives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to autoinduction of oxidative enzymes involved in AG metabolism. 
3  9999  B.M. Nzimbi, G.P. Pokhariyal And S.K. Moindi, A Note On Metric Equivalence Of Operators, Far East Math Jourmal (FMJS), Accepted March 2012, To Appear. Click to View Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG halflife was 19.5 +/ 7.7 h in seven fast acetylators of DDS and 12.6 +/ 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/ 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/ 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/ 1.5% by fast and 1.9 +/ 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the halflives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to autoinduction of oxidative enzymes involved in AG metabolism. 
4  9999  B.M. Nzimbi, G.P. Pokhariyal And S.K. Moindi, A Note On Aselfadjoint And Askewadjoint Operators And Their Extensions, Pioneer Journal Of Mathematics And Mathematical Sciences, Accepted January, 2012, To Appear Click to View Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG halflife was 19.5 +/ 7.7 h in seven fast acetylators of DDS and 12.6 +/ 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/ 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/ 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/ 1.5% by fast and 1.9 +/ 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the halflives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to autoinduction of oxidative enzymes involved in AG metabolism. 
5  9999  Justus K. Mile, Bernard M. Nzimbi And S.K. Moindi, On The Characterization Of Class R_1 Of Nonnormal Operators In A Hilbert Space, Pioneer Journal Of Mathematics And Mathematical Sciences(PMMS), Accepted March 2012, To Appear. Click to View Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG halflife was 19.5 +/ 7.7 h in seven fast acetylators of DDS and 12.6 +/ 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/ 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/ 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/ 1.5% by fast and 1.9 +/ 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the halflives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to autoinduction of oxidative enzymes involved in AG metabolism. 
6  2012  W_4Curvature Tensor On A AEinstein Sasakian Manifold, Global Journal Of Theoretical And Applied Mathematical Sciences(GJTAMS), Accepted Feb 2012, To Appear. Click to View Abstract

7  2010  Stephen Moindi Kibet, G.P. Pokhariyal And B.M. Nzimbi, Study Of W_4 Curvature Tensor On Sasakian Manifold, Kenya J. Sciences(KJS), Vol. 14, No.1 2010, 18 Click to View Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG halflife was 19.5 +/ 7.7 h in seven fast acetylators of DDS and 12.6 +/ 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/ 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/ 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/ 1.5% by fast and 1.9 +/ 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the halflives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to autoinduction of oxidative enzymes involved in AG metabolism. 